CC Cardiol Croat Cardiologia Croatica Cardiol. Croat. 1848-543X 1848-5448 Croatian Cardiac Society CC_11(10-11)_474 10.15836/ccar2016.474 Extended Abstract Impact of thrombocytopenia after transcatheter aortic valve implantation on short term clinical outcomes http://orcid.org/0000-0002-4721-3236LukšićVlatka Rešković1http://orcid.org/0000-0003-1762-9270OstojićZvonimir1http://orcid.org/0000-0002-0884-4043KolarićBranko2http://orcid.org/0000-0002-8070-1012VečerićSandra1http://orcid.org/0000-0003-4519-5940ŠafradinIvica1http://orcid.org/0000-0003-4596-8261StrozziMaja1http://orcid.org/0000-0002-1482-6503BulumJoško1http://orcid.org/0000-0002-3437-6407HanževačkiJadranka Šeparović1 University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb,Croatia University of Rijeka School of Medicine, Rijeka, Croatia Address for correspondence: Vlatka Rešković Lukšić, Klinički bolnički centar Zagreb, Kišpatićeva 12, HR-10000 Zagreb, Croatia. / Phone: +385-1-236-7491 / E-mail: vlatka.reskovic@gmail.com 112016 11 10-11 474 474 2509201610102016 2016 Croatian Cardiac Society Keywords: transcatheter aortic valve implantationthrombocytopenia

Background. Thrombocytopenia (TP) after transcatheter aortic valve implantation (TAVI) has been observed, but not well studied. We aimed to investigate incidence and clinical significance of TP associated with TAVI. (1-3)

Patients and Methods: A total of 42 patients who underwent successful TAVI (37 CoreValve, 5 Edwards Sapien) in University Hospital Center Zagreb were enrolled. Platelet (PT) and hemoglobin (Hgb) count were analyzed before, on day 3-4 after TAVI and before discharge (about 1 week after the procedure). Transfusion units and clinical complications were recorded.

Results: Before the procedure, Hgb level was 126 (93-161) g/l, and platelet count 197 (101-369) × 109/L. On day 3-4 after the procedure, significant drop of Hgb (104 (86-142) g/l, p <0.001) and PT (167,5 (83-297) × 109/L, p <0.001) was observed with significant correlations between variables. In 12 (28.6%) pts, moderate/severe TP (PT<100× 109/L) occurred. In this group of pts, drop in Hgb levels showed no significant difference compared to those pts with no significant TP. None of the pts required PT transfusion. There were 3 major bleedings in non-TP group and none in TP group. 11 units of red blood cells (0.92 per patient) were used in TP group, and 26 units (0.87 per patient) in non-TP group After one week, PT levels showed significant recovery toward normal values (199 (66-333) × 109/L, p=0.014), while Hgb levels showed no significant recovery (105 (88-130) g/l, p=0.286) and remained significantly lower compared to baseline (p=0.001). PT count after one week showed no significant difference compared to preprocedural values (p=0.989); only in 1 patient PT count remained low after 1 week.

Conclusion. TP after TAVI is common, self-limited process. It occurs 3-4 days after TAVI with complete recovery of PT count during 1 week. In the short term follow up, it has no impact on Hgb level, incidence of major bleeding nor need for transfusion. Etiology of this phenomenon remaines unresloved.

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