Introduction: Weight loss can result in reduction of multiple cardiovascular risk factors, as well as cardiac structural and functional remodeling. (1-3)

Patients and Methods: We enrolled 79 obese patients (37 in control group, 42 in intensive weight loss program). All patients were followed in cardiology outpatient department for 12 months, with a 3-month follow-up period. They were all advised to improve life-style and diet habits. All patients underwent initial and final cardiovascular risk assessment, echocardiography, exercise stress testing, ECG Holter monitoring and 24-hour blood pressure monitoring.

Results: We observed statistically significant improvement in LA and RA volumes, reduced ventricular mass, systolic blood pressure and improved functional capacity on treadmill test. Insulin resistance based on HOMA model also improved, with a significant fall in proinflammatory marker CRP. ECG Holter monitoring revealed significant reduction of AF episodes and SVPBs. Structural changes between groups were independent of the body surface area.

Conclusion: Structured weight loss program leads to improved cardiometablic risk management, with reduced insulin resistance and modulation of inflammation. Significant reduction in cardiac volumes, blood pressure and added functional benefit was observed. Suppressed supraventricular arrhythmogenicity is hypothesized to reflect structural and electrical remodeling of the heart.