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<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.0 20120330//EN" "JATS-journalpublishing1.dtd">
<article article-type="abstract" dtd-version="1.0" xml:lang="en" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">CC</journal-id>
<journal-id journal-id-type="nlm-ta">Cardiol Croat</journal-id>
<journal-title-group>
<journal-title>Cardiologia Croatica</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Cardiol. Croat.</abbrev-journal-title>
</journal-title-group>
<issn pub-type="ppub">1848-543X</issn>
<issn pub-type="epub">1848-5448</issn>
<publisher><publisher-name>Croatian Cardiac Society</publisher-name></publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">CC_11(12)_628-629</article-id>
<article-id pub-id-type="doi">10.15836/ccar2016.628</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Extended Abstract</subject></subj-group>
</article-categories>
<title-group>
<article-title>Outpatient cardiovascular rehabilitation after aortic valve surgery: Croatian experience</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-3888-4804</contrib-id><name><surname>Skori&#x0107;</surname><given-names>Kristina Naran&#x010D;i&#x0107;</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-6426-6831</contrib-id><name><surname>Ivanu&#x0161;a</surname><given-names>Mario</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-8804-1357</contrib-id><name><surname>Dra&#x017E;i&#x0107;-Balov</surname><given-names>Jadranka</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-6037-7537</contrib-id><name><surname>Muminovi&#x0107;</surname><given-names>&#x017D;aklina</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib>
<aff id="aff1"><label>1</label>Institute for Cardiovascular Prevention and Rehabilitation, Zagreb, <country>Croatia</country></aff>
<aff id="aff2"><label>2</label>University of Rijeka School of Medicine, Rijeka, <country>Croatia</country></aff>
</contrib-group>
<author-notes>
<corresp id="cor1">Address for correspondence: Mario Ivanu&#x0161;a, Poliklinika za prevenciju kardiovaskularnih bolesti i rehabilitaciju, Dra&#x0161;kovi&#x0107;eva 13, HR-10000 Zagreb, Croatia. / Phone: +385-1-4612-290; Fax: +385-1-4612-343 / E-mail: <email xlink:href="mivanusa@gmail.com">mivanusa@gmail.com</email></corresp></author-notes>
<pub-date pub-type="epub-ppub"><month>11</month><year>2016</year></pub-date>
<volume>11</volume>
<issue>12</issue>
<fpage>628</fpage>
<lpage>629</lpage>
<history>
<date date-type="received"><day>10</day><month>11</month><year>2016</year></date><date date-type="accepted"><day>20</day><month>11</month><year>2016</year></date>
</history>
<permissions>
<copyright-year>2016</copyright-year>
<copyright-holder>Croatian Cardiac Society</copyright-holder>
</permissions>
<kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>aortic valve surgery</kwd><kwd>outpatient cardiovascular rehabilitation</kwd><kwd>Croatia</kwd></kwd-group>
</article-meta>
</front>
<body>
<p><bold>Introduction:</bold> While the benefits of the cardiovascular rehabilitation (CVR) after the myocardial surgical coronary revascularization are well documented, only a few studies have indicated the benefits of CVR in patients after the aortic valve surgery. (<xref ref-type="bibr" rid="r1"><italic>1</italic></xref>, <xref ref-type="bibr" rid="r2"><italic>2</italic></xref>) The aim of the paper is to show the experience of the only Croatian center of the outpatient CVR in patients after the aortic valve surgery.</p>
<p><bold>Patients and Methods:</bold> We retrospectively analyzed the data from the medical charts of all patients with operated aortic valve involved in the outpatient CVR program in the Institute for Cardiovascular Diseases Prevention and Rehabilitation in Zagreb from 10th January 2012, and who ceased to participate in the program by 6th October 2016. The performance of the CVR program in the Insitute has already been described. (<xref ref-type="bibr" rid="r3"><italic>3</italic></xref>) In addition to the data on a type of intervention and risk factors, we have also analyzed the frequency of the optimally performed anticoagulant therapy (<xref ref-type="bibr" rid="r4"><italic>4</italic></xref>) and changes to the functional capacity at the end of the CVR. The results were presented by groups according to gender by using the descriptive statistics methods.</p>
<p><bold>Results:</bold> Out of 53 patients involved, 18 (34%) were women and 35 (66%) men. The average duration of CVR was 2.6 months. The main disease is aortic stenosis, which was present in 80% of men and 89% of women. The analysis of the frequency of the interventions performed, risk factors and the success of anticoagulant therapy is shown in <xref ref-type="table" rid="t1"><bold>Table 1</bold></xref>. The mean functional capacity value at the beginning and end of the CVR was 5.9&#x00B1;1.39 and 6.8&#x00B1;1.17 for men and 5.6&#x00B1;0.85 and 6.4&#x00B1;1,12 METs for women.</p>
<table-wrap id="t1" position="float">
<label>Table 1</label><caption><title>The frequency of performed cardiac surgeries, risk factors and success of anticoagulant therapy in patients undergoing outpatient cardiovascular rehabilitation following aortic valve surgery.</title></caption>
<table frame="hsides" rules="groups">
<col width="40.75%"/>
<col width="12.42%"/>
<col width="15.76%"/>
<col width="14.86%"/>
<col width="16.21%"/>
<thead>
<tr>
<th colspan="2" valign="top" align="left" scope="colgroup" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"></th>
<th valign="top" align="left" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"><bold>Men</bold><break/><bold>n = 35</bold></th>
<th valign="top" align="left" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"><bold>Women</bold><break/><bold>n = 18</bold></th>
<th valign="top" align="left" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"><bold>All</bold><break/><bold>N = 53</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.50pt; border-bottom: solid 0.25pt" scope="row"><bold>Aortic stenosis</bold></td>
<td valign="top" align="left" style="border-left: solid 0.50pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"></td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">80.0% (28/35)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">88.9% (16/18)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">83.0% (44/53)</td>
</tr>
<tr>
<td colspan="5" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="col"><bold>Aortic Valve Replacement Surgery</bold></td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.50pt; border-bottom: solid 0.75pt" scope="row"><bold>Bioprosthetic aortic valve replacement</bold></td>
<td valign="top" align="left" style="border-left: solid 0.50pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.75pt"></td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">54.3% (19/35)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">66.7% (12/18)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">58.5% (31/53)</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.75pt; border-right: solid 0.75pt; border-bottom: solid 0.75pt" scope="row">&#x2013; bioprosthesis + coronary artery bypass grafting</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">26.3% (5/19)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">25.0% (3/12)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">25.8% (8/31)</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.75pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">&#x2013; bioprosthesis + surgery of ascending aorta</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">0% (0/19)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">8.3% (1/12)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">3.2% (1/31)</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.75pt" scope="row"><bold>Mechanical aortic valve replacement</bold></td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">45.7% (16/35)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">27.8% (5/18)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">39.6% (21/53)</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.75pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">&#x2013; mechanical prostheses + surgery of ascending aorta</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">37.5% (6/16)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">20.0% (1/5)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">33.3% (7/21)</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.50pt; border-bottom: solid 0.25pt" scope="row"><bold>Transcatheter aortic valve implantation</bold></td>
<td valign="top" align="left" style="border-left: solid 0.50pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"></td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">0% (0/35)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">5.6% (1/18)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">1.9% (1/53)</td>
</tr>
<tr>
<td colspan="5" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="col"><bold>Risk factors</bold></td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Average age &#x00B1; standard deviation (years)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">64 &#x00B1; 12.4</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">70 &#x00B1; 8.9</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">66.1 &#x00B1; 11.6</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Age range (minimum-maximum; years)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">28-81</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">41-80</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">28-81</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Hypertension</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">85.7% (30/35)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">77.8% (14/18)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">83.0% (44/53)</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Dyslipidemia</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">80.0% (28/35)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">66.7% (12/18)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">75.5% (40/53)</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Diabetes</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">25.7% (9/35)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">11.1% (2/18)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">20.8% (11/53)</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Active smoking</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">17.1% (6/35)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">27.8% (5/18)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">20.8% (11/53)</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Coronary artery disease</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">31.4% (11/35)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">38.9% (7/18)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">34.0% (18/53)</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Mean body mass indeks (kg/m<sup>2</sup>)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">28</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">27.9</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">28.2</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Overweight</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">71.4% (25/35)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">50.0% (9/18)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">64.2% (34/53)</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Obesity</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">17.1% (6/35)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">22.2% (4/18)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">18.9% (10/53)</td>
</tr>
<tr>
<td colspan="2" valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Optimaly anticoagulated patients with indications (time in target range of PV/INR)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">55.0% (15/27)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">55.0% (5/9)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">55.0% (20/36)</td>
</tr>
</tbody></table></table-wrap>
<p><bold>Conclusions:</bold> Men are more often involved in the outpatient CVR program following the aortic valve surgery. Aortic stenosis is a dominant disease, where out of risk factors there is hypertension, dyslipidemia and increased body mass index to be emphasized. Patients with implanted bioprosthetic valve were involved more frequently. Anticoagulant therapy was optimal in a half of the subjects. The CVR program after the aortic valve replacement surgery improves the functional capacity. Further studies on a greater number of patients as well as additional education about the importance of anticoagulant therapy are needed.</p>
</body>
<back>
<ref-list>
<title>Literature</title>
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