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<article article-type="abstract" dtd-version="1.0" xml:lang="en" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">CC</journal-id>
<journal-id journal-id-type="nlm-ta">Cardiol Croat</journal-id>
<journal-title-group>
<journal-title>Cardiologia Croatica</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Cardiol. Croat.</abbrev-journal-title>
</journal-title-group>
<issn pub-type="ppub">1848-543X</issn>
<issn pub-type="epub">1848-5448</issn>
<publisher><publisher-name>Croatian Cardiac Society</publisher-name></publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">CC_13(1-2)_51</article-id>
<article-id pub-id-type="doi">10.15836/ccar2018.51</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Extended Abstract</subject></subj-group>
</article-categories>
<title-group>
<article-title>Venovenous extracorporeal membrane oxygenation in a patient with acute respiratory distress syndrome caused by drowning</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-3197-2190</contrib-id><name><surname>Pa&#x0161;ali&#x0107;</surname><given-names>Marijan</given-names></name><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-5979-2346</contrib-id><name><surname>Skori&#x0107;</surname><given-names>Bo&#x0161;ko</given-names></name></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-4772-5549</contrib-id><name><surname>&#x010C;ike&#x0161;</surname><given-names>Maja</given-names></name></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-5052-6559</contrib-id><name><surname>Lovri&#x0107;</surname><given-names>Daniel</given-names></name></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-7171-2206</contrib-id><name><surname>Ljubas Ma&#x010D;ek</surname><given-names>Jana</given-names></name></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-2599-553X</contrib-id><name><surname>Jurin</surname><given-names>Hrvoje</given-names></name></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-9346-6402</contrib-id><name><surname>Samard&#x017E;i&#x0107;</surname><given-names>Jure</given-names></name></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-1482-6503</contrib-id><name><surname>Bulum</surname><given-names>Jo&#x0161;ko</given-names></name></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-9101-1570</contrib-id><name><surname>Mili&#x010D;i&#x0107;</surname><given-names>Davor</given-names></name></contrib>
<aff id="aff1">University of Zagreb School of Medicine, <institution>University Hospital Centre Zagreb</institution>, <addr-line>Zagreb</addr-line>, <country>Croatia</country></aff>
</contrib-group>
<author-notes>
<corresp id="cor1"><label>*</label>ADDRESS FOR CORRESPONDENCE: Marijan Pa&#x0161;ali&#x0107;, Klini&#x010D;ki bolni&#x010D;ki centar Zagreb, Ki&#x0161;pati&#x0107;eva 12, HR-10000 Zagreb, Croatia. / Phone: +385-1-2367-467 / E-mail: <email xlink:href="marijan.pasalic@yahoo.com">marijan.pasalic@yahoo.com</email></corresp></author-notes>
<pub-date pub-type="epub-ppub"><month>02</month><year>2018</year></pub-date>
<volume>13</volume>
<issue>1-2</issue>
<fpage>51</fpage>
<lpage>52</lpage>
<history>
<date date-type="received"><day>04</day><month>02</month><year>2018</year></date><date date-type="accepted"><day>10</day><month>02</month><year>2018</year></date>
</history>
<permissions>
<copyright-year>2018</copyright-year>
<copyright-holder>Croatian Cardiac Society</copyright-holder>
</permissions>
<kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>venovenous extracorporeal membrane oxygenation</kwd><kwd>drowning</kwd><kwd>acute respiratory distress syndrome</kwd></kwd-group>
</article-meta>
</front>
<body>
<p><bold>Introduction</bold>: Benefits of venovenous extracorporeal membrane oxygenation (VV-ECMO) in patients with severe acute respiratory failure (RF) have been identified in different trials (<xref ref-type="bibr" rid="r1"><italic>1</italic></xref>). Due to surfactant washout, drowning often results in acute respiratory distress syndrome (ARDS), which remains the most important cause of death in those patients surviving the transfer to hospital.</p>
<p><bold>Case report</bold>: 32-year-old male patient with no prior medical history presented to our Emergency Department following drowning and a successful resuscitation. He was found submerged in the pool just a couple of minutes after being seen conscious and swimming. Lifeguard on duty pulled him out of the pool and started cardiopulmonary resuscitation. Upon the arrival of Emergency Medical Service, patient had a pulse and was breathing spontaneously, but was exhibiting grand mal seizures and not recovering consciousness. In the emergency department he was put on mechanical ventilation (MV) due to global RF and in the Coronary Care Unit therapeutic hypothermia (TH) was started. Urgent diagnostics was performed and no signs of stroke, coronary artery disease, pulmonary embolism or significant electrolyte imbalance were detected. 12-lead ECG and echocardiography showed no abnormal findings despite severe respiratory acidosis. Due to signs of ARDS (<xref ref-type="fig" rid="f1"><bold>Figure 1</bold></xref>) and worsening RF in spite of increasing MV support, VV ECMO implantation was indicated. It was successfully conducted in the early period (&lt;3 hours) in order to achieve rapid normalization of blood gas levels and optimal conditions for neurologic recovery. Considering profuse aspiration, ceftriaxone and clindamycin were initiated. Following the 24 hours protocol for TH and discontinuation of sedation, patient gradually recovered consciousness. Due to persistent diffuse pulmonary infiltrates and detection of Pseudomonas in endotracheal aspirate samples, cefepime and methylprednisolone were administered. In the following days X-rays showed resolution of ARDS (<xref ref-type="fig" rid="f2"><bold>Figure 2</bold></xref>) and patient&#x2019;s respiratory function significantly improved. Hence, he was successfully weaned of ECMO (5<sup>th</sup> day) and of MV (8<sup>th</sup> day). He exhibited no signs of neurologic deficit and was rapidly mobilized. Finally, on the 21<sup>st</sup> day he was discharged home.</p>
<fig id="f1" position="float" fig-type="figure"><label>FIGURE 1</label><caption><p>MSCT findings showing diffuse pulmonary (parenchimal) infiltrates and radiologic signs of acute respiratory distress syndrome.</p></caption><graphic xlink:href="CC_13(1-2)_51-f1"></graphic></fig>
<fig id="f2" position="float" fig-type="figure"><label>FIGURE 2</label><caption><p>X-ray findings before and after methylprednisolone and cefepime therapy.</p></caption><graphic xlink:href="CC_13(1-2)_51-f2"></graphic></fig>
<p><bold>Conclusion</bold>: Our case report recognizes the potential life-saving role of VV-ECMO in treating drowning patients with severe ARDS. Hence, the use of ECMO should be beared in mind as a treatment modality in all drowning victims.</p>
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<ref-list>
<title>LITERATURE</title>
<ref id="r1"><label>1</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Peek</surname><given-names>GJ</given-names></name><name><surname>Mugford</surname><given-names>M</given-names></name><name><surname>Tiruvoipati</surname><given-names>R</given-names></name><name><surname>Wilson</surname><given-names>A</given-names></name><name><surname>Allen</surname><given-names>E</given-names></name><name><surname>Thalanany</surname><given-names>MM</given-names></name><etal/></person-group> <article-title>CESAR trial collaboration. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial.</article-title> <source>Lancet</source>. <year>2009</year> Oct 17;<volume>374</volume>(<issue>9698</issue>):<fpage>1351</fpage>&#x2013;<lpage>63</lpage>. <pub-id pub-id-type="doi">10.1016/S0140-6736(09)61069-2</pub-id><pub-id pub-id-type="pmid">19762075</pub-id></mixed-citation></ref>
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