CCCardiol CroatCardiologia CroaticaCardiol. Croat.1848-543X1848-5448Croatian Cardiac SocietyCC_13(11-12)_40010.15836/ccar2018.400Extended AbstractRatio of end systolic volume over left atrial area is a respectable yardstick of systolic impairment in non-ischemic cardiomyopathiesOmjer sistoličkog volumena u terminalnoj dijastoli s površinom lijevog atrija predstavlja dobar dijagnostički pokazatelj sistoličke disfunkcije kod bolesnika s neishemijskom kardiomiopatijomhttps://orcid.org/0000-0002-6129-575XBobanMarko12*Klinički bolnički centar Sestre milosrdnice, Zagreb, HrvatskaSveučilište Josipa Jurja Strossmayera u Osijeku, Fakultet za dentalnu medicinu i zdravstvo Osijek, Osijek, HrvatskaUniversity Hospital Centre “Sestre milosrdnice”, Zagreb, CroatiaJosip Juraj Strossmayer University of Osijek, Faculty of Dental Medicine and Health Osijek, Osijek, CroatiaADDRESS FOR CORRESPONDENCE: Marko Boban, Klinički bolnički centar Sestre milosrdnice, Vinogradska 29, HR-10000 Zagreb, Croatia. / Phone: +385-1-3787-111 / E-mail: marcoboban@yahoo.com1120181311-1240040025102018051120182018Croatian Cardiac SocietyKLJUČNE RIJEČI: magnetska rezonancija srcaneishemijska kardiomiopatijakasno bojanje gadolinijemKEYWORDS: cardiac magnetic resonancenon-ischemic cardiomyopathylate gadolinium enhancement
Background: Impairment of systolic function and late gadolinium enhancement (LGE) are well known negative prognostic markers in non-ischemic cardiomyopathies (NICMPs). (1, 2) The aim of our study was to analyze power of connection existing between individual volumetric parameters over left atrial area and systolic dysfunction or existence of LGE in patients with non-ischemic cardiomyopathy and healthy controls.
Patients and Methods: Consecutive cases of NICMPs and controls were included from computerized data base of cardiac magnetic resonance exams for 2.6-year period. Ratios made from volumetric parameters over left atrial area (LAA) were calculated.
Results: Study included 210 cases referred to cardiac magnetic resonance (CMR); age was 49.6±16.9 years (range 15.2-79.3), male to female ratio 132 (62.9%) vs 78 (37.1%). LGE significantly correlated with impairment of systolic function (Rho CC=0.338; p<0.001), and linear-LGE as well (Rho CC=0.430; p<0.001). For detection of systolic impairment, a critical value of End-systolic-volume(ESV)/LAA of ≥2.6 had area under curve (AUC) 0.910 (0.862-0.945), p<0.001; stroke-volume(SV)/LAA had AUC=0.814 (0.754-0.864), p<0.001 and end-diastolic-volume (EDV)/LAA had AUC 0.653 (0.584-0.718); p<0.001. ESV/LAA correlated with systolic dysfunction (Rho-correlation-coefficient:0.604; p<0.001) and existence of linear midventricular LGE stripe (Rho-CC=0.286; p<0.001).
Conclusions: ESV/LAA was the most effective of studied parameters for detection of systolic dysfunction and also connected with existence of LGE. Prospective validation of cardiac remodeling for prognostic significance would be needed in future studies.
LITERATUREBobanMPesaVPersicVZuljMMalcicIBeckNOverlapping Phenotypes and Degree of Ventricular Dilatation Are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies. . 2018 Jul 22;24:5084–92. 10.12659/MSM.90917230032158BobanMPesaVGabricIDManolaSPersicVAntic-KauzlaricHAuxiliary diagnostic potential of ventricle geometry and late gadolinium enhancement in left ventricular non-compaction; non-randomized case control study. . 2017 Dec 6;17(1):286. 10.1186/s12872-017-0721-029207943