Percutaneous interventions on lesions in aortoiliac localization have been in focus of interest from the very beginning of interventions because of anatomic suitability and very good short and long-term results. New guidelines from European Society of Cardiology on Peripheral Artery Disease (1) published in 2017 made changes in categorization of lesions by abandoning TASC II classification. Endovascular approach has I C recommendation for first choice treatment of occlusive lesions up to 5 cm in length. More complex lesions should be considered for endovascular-first strategy in patients with severe comorbidities. In general, endovascular treatment of peripheral artery disease in aortoiliac localization has a very important role after optimal medicament treatment and supervised exercise training.