Venous thromboembolism represents a significant public health issue – it is the third most common cardiovascular disease in Europe. (1-3) In University Hospital Centre Osijek we admitted a total of 193 patients for venous thromboembolism. We diagnosed deep vein thrombosis in 51.3% and pulmonary embolism in 48.7% of those patients. The average age of patients was 65.5 years, 46.6% were male and 53.4% were female. A recurrent venous thromboembolism was present in 8.8% of patients, and 21.2% had a previously diagnosed malignancy. The most common comorbidity was arterial hypertension. During the hospitalization patients were treated with low-molecular weight heparin. We discharged 48.2% of the patients on direct oral anticoagulants, 26.9% on warfarin and 23.3% on low-molecular weight heparin. Since venous thromboembolism is one of the leading causes of cardiovascular mortality, the aim of this study was to compare clinical practice data from our center with data from previously published international registries. After examining the results, we can conclude that there are many similarities and some differences between patients in our cohort and those from other registries. Since there is no objective data (national registry) available in Croatia, we wish to present the current clinical information about patients with venous thromboembolism in our center and explore questions about the situation in other centers and regions.