Takotsubo syndrome (broken heart syndrome) was first described in Japan. Its characteristics are regional systolic left ventricular dysfunction. Prevalence is currently estimated at 1% to 2% of patients with suspected acute coronary syndrome (ACS), but related with emotional or physical stress. (1, 2) Although the exact pathophysiology isn’t fully elaborated. Despite the fact that this syndrome had high rate of survival and positive reaction to treatment we can link broken heart syndrome with lethal complications that cause death of patients as high as 5%. In University Hospital Dubrava golden standard for differential diagnosis is coronary angiography with ventriculography and it requires exceptional education all involved personnel.