CC Cardiol Croat Cardiologia Croatica Cardiol. Croat. 1848-543X 1848-5448 Croatian Cardiac Society CC 2019 14_9-10_222 10.15836/ccar2019.222 Extended Abstract Outcomes in patients with heart failure with regard to statin therapy https://orcid.org/0000-0002-3697-8006GodinjakAmina1* https://orcid.org/0000-0001-8760-6192ĐeševićMiralem1 https://orcid.org/0000-0002-4677-8489IglicaAmer2 https://orcid.org/0000-0002-4900-5094KukuljacAdis3 Eurofarm Centar Medical Clinic, Sarajevo, Bosnia and Herzegovina Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina General Hospital Sarajevo, Sarajevo, Bosnia and HerzegovinaKEYWORDS: heart failure, statin therapy, outcome. ADDRESS FOR CORRESPONDENCE: Amina Godinjak, Fra Anđela Zvizdovića 1, 71000 Sarajevo, Bosnia and Herzegovina. / Phone: +38761187010 / Email: aminagodinjak@gmail.com 102019 14 9-10 222 222 29072019 16092019 2019 Croatian Cardiac Society

Objective: The aim of this study was to investigate whether statin therapy influenced outcomes in patients with acute heart failure (HF). (1, 2)

Patients and Methods: Eighty five patients with diagnosis of HF were included in the study. For each patient the following data were obtained: gender, age, comorbidities and medications. New York Heart association (NYHA) class for heart failure was determined by physician evaluation and left ventricle ejection fraction (LVEF) was determined by echocardiography. Outcome points were: hospitalization, in-hospital death, mortality after 6 months, 1 year and 2 years. All-cause mortality included cardiovascular events or worsening heart failure.

Results: Mortality after 6 months, 1 year and 2 years was the most frequent in patients without statin therapy with a statistically significant difference (p = 0.001). Progression of HF accounted for 31.7% of mortality in patients without statin therapy.

Conclusion: Statin therapy is associated with substantially better long-term outcomes in patients with HF.

LITERATURE AlehagenUBensonLEdnerMDahlströmULundLH. Association between use of statins and outcomes in heart failure with reduced ejection fraction: prospective propensity score matched cohort study of 21 864 patients in the Swedish Heart Failure Registry. Circ Heart Fail. 2015 Mar;8(2):252–60. 10.1161/CIRCHEARTFAILURE.114.00173025575580 PreissDCampbellRTMurrayHMFordIPackardCJSattarN The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials. Eur Heart J. 2015 Jun 21;36(24):1536–46. 10.1093/eurheartj/ehv07225802390