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<article article-type="abstract" dtd-version="1.0" xml:lang="en" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">CC</journal-id>
<journal-id journal-id-type="nlm-ta">Cardiol Croat</journal-id>
<journal-title-group>
<journal-title>Cardiologia Croatica</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Cardiol. Croat.</abbrev-journal-title>
</journal-title-group>
<issn pub-type="ppub">1848-543X</issn>
<issn pub-type="epub">1848-5448</issn>
<publisher><publisher-name>Croatian Cardiac Society</publisher-name></publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">CC 2019 14_9-10_230-1</article-id>
<article-id pub-id-type="doi">10.15836/ccar2019.230</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Extended Abstract</subject></subj-group>
</article-categories>
<title-group>
<article-title>Comparison of the 3-class and 5-class grading schemes for quantification of paravalvular regurgitation during transcatheter aortic valve implantation</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1762-9270</contrib-id><name><surname>Ostoji&#x0107;</surname><given-names>Zvonimir</given-names></name><xref ref-type="corresp" rid="cor1">*</xref></contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4721-3236</contrib-id><name><surname>Re&#x0161;kovi&#x0107; Luk&#x0161;i&#x0107;</surname><given-names>Vlatka</given-names></name></contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1134-4856</contrib-id><name><surname>Glava&#x0161; Konja</surname><given-names>Blanka</given-names></name></contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1542-2890</contrib-id><name><surname>Mance</surname><given-names>Marija</given-names></name></contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4519-5940</contrib-id><name><surname>&#x0160;afradin</surname><given-names>Ivica</given-names></name></contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1482-6503</contrib-id><name><surname>Bulum</surname><given-names>Jo&#x0161;ko</given-names></name></contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3437-6407</contrib-id><name><surname>&#x0160;eparovi&#x0107; Han&#x017E;eva&#x010D;ki</surname><given-names>Jadranka</given-names></name></contrib>
<aff id="aff1">University of Zagreb School of Medicine, <institution>University Hospital Centre Zagreb</institution>, <addr-line>Zagreb</addr-line>, <country>Croatia</country></aff>
</contrib-group>
<author-notes>
<corresp id="cor1"><label>*</label>ADDRESS FOR CORRESPONDENCE: Zvonimir Ostoji&#x0107;, Klini&#x010D;ki bolni&#x010D;ki centar, Ki&#x0161;pati&#x0107;eva 12, HR-10000 Zagreb, Croatia. / Phone: +385-91-8950-702 / E-mail: <email xlink:href="ostojiczvonimir@gmail.com">ostojiczvonimir@gmail.com</email></corresp></author-notes>
<pub-date pub-type="epub-ppub"><month>10</month><year>2019</year></pub-date>
<volume>14</volume>
<issue>9-10</issue>
<fpage>230</fpage>
<lpage>231</lpage>
<history>
<date date-type="received"><day>08</day><month>09</month><year>2019</year></date>
<date date-type="accepted"><day>16</day><month>09</month><year>2019</year></date>
</history>
<permissions>
<copyright-year>2019</copyright-year>
<copyright-holder>Croatian Cardiac Society</copyright-holder>
</permissions>
<kwd-group kwd-group-type="author"><title>KEYWORDS: </title><kwd>cardiovascular imaging</kwd><kwd>transesophageal echocardiography</kwd><kwd>transcatheter aortic valve implantation</kwd><kwd>paravalvular regurgitation</kwd></kwd-group>
</article-meta>
</front>
<body>
<p><bold>Introduction</bold>: More than mild paravalvular regurgitation (PVR) after transcatheter aortic valve implantation (TAVI) represents one of the negative predictive factor for survival and quality of life after TAVI (<xref ref-type="bibr" rid="r1"><italic>1</italic></xref>). However, quantification and definition of more than mild PVR remains to be unified. Most commonly used 3 stage grading scheme is often insufficient (<xref ref-type="bibr" rid="r2"><italic>2</italic></xref>). Aim of this research was to assess differences in incidence of more than mild PVR during and after TAVI comparing 3 and 5 grades staging schemes.</p>
<p><bold>Patients and Methods</bold>: Study included 40 patients that underwent TAVI between July 2016 and January 2019 in general anesthesia with transesophageal echocardiography (TEE) during procedure. TEE exams had to be sufficiently recorded to quantify PVR with both grading schemes. Parameters used for PVR quantification and differences between models are presented in <xref ref-type="table" rid="t1"><bold>Table 1</bold></xref>.</p>
<table-wrap id="t1" position="float">
<label>TABLE 1</label><caption><title>Transesophageal echocardiography parameters used for paravalvular regurgitation quantification in the 3-class and 5-class grading schemes.</title>
</caption>
<table frame="hsides" rules="groups">
<col width="24.51%"/>
<col width="11.64%"/>
<col width="16.88%"/>
<col width="15.17%"/>
<col width="17.4%"/>
<col width="14.4%"/>
<thead>
<tr>
<th valign="middle" align="center" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"><bold>3-class grading scheme</bold></th>
<th valign="middle" colspan="2" align="center" scope="colgroup" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Trace/mild</th>
<th valign="middle" colspan="2" align="center" scope="colgroup" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Moderate</th>
<th valign="middle" align="center" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Severe</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Circumferential extent of PVR (%) assessed with CD</td>
<td valign="middle" colspan="2" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">1-20</td>
<td valign="middle" colspan="2" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">20-30</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">&gt;30</td>
</tr>
<tr>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row"><bold>5-class grading scheme</bold></td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Trace/mild</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Mild to moderate</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Moderate</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Moderate to sever</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Sever</td>
</tr>
<tr>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Valve stent shape</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Normal</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Usually normal</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Often elliptical/abnormal</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Usually elliptical/abnormal</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Elliptical/<break/>abnormal</td>
</tr>
<tr>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">&gt;1 regurgitation jet</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">No</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Possible</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Often present</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Usually present</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Usually present</td>
</tr>
<tr>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Regurgitation jet visible</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">No</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Possible</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Often visible</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Usually visible</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Visible</td>
</tr>
<tr>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Jet with at its origin (% of LVOT diameter) assessed with CD</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">1-15</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">15-30</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">30-45</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">45-60</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">&gt;60</td>
</tr>
<tr>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Circumferential extent of PVR (%) assessed with CD</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">&lt;10</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">10-20</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">20-30</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">&gt;30</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">&gt;30</td>
</tr>
<tr>
<td valign="middle" colspan="6" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.75pt" scope="col">PVR &#x2013; paravalvular regurgitation; CD &#x2013; color Doppler; LVOT &#x2013; left ventricle outflow tract.</td>
</tr>
</tbody></table></table-wrap>
<p><bold>Results</bold>: After initial valve implantation 10 (25%) patients had more than mild PVR when quantified using 3 grade model compared to 19 (47.5%) using 5 grade model (p&lt;0.001). Furthermore, 2 patients with severe PVR assessed by 5 stage model were stratified as having moderate PVR using 3 stage model. In total 14 (35%) patients underwent postdilatation and in 3 (7.5%) of them additional valve was implanted. As final result more than mild PVR was present in 2 (5%) patients using 3 grade model and in 12 (30%) using 5 grade model (p=0.027). Detailed stratification of PVR severity is presented in <xref ref-type="table" rid="t2"><bold>Table 2</bold></xref>.</p>
<table-wrap id="t2" position="float">
<label>TABLE 2</label><caption><title>Detailed analysis of paravalvular regurgitation severity between compared models after initial valve implantation and at the end of procedure.</title>
</caption>
<table frame="hsides" rules="groups">
<col width="21.5%"/>
<col width="21.65%"/>
<col width="18.95%"/>
<col width="18.95%"/>
<col width="18.95%"/>
<thead>
<tr>
<th valign="top" align="left" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"></th>
<th valign="top" align="center" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"><bold>3-class staging scheme</bold></th>
<th valign="top" align="center" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"><bold>5-class staging scheme</bold></th>
<th valign="top" align="center" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"><bold>3-class staging scheme</bold></th>
<th valign="top" align="center" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"><bold>5-class staging scheme</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row"></td>
<td valign="middle" colspan="2" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"><bold>after initial implantation</bold></td>
<td valign="middle" colspan="2" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt"><bold>end of procedure</bold></td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">None &#x2013; N(%)</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">5 (12.5)</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">5 (12.5)</td>
<td valign="top" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">5 (12.5)</td>
<td valign="top" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">5 (12.5)</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Trace or mild &#x2013; N(%)</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">25 (62.5)</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">16 (40)</td>
<td valign="top" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">33 (82.5)</td>
<td valign="top" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">23 (57.5)</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Mild to moderate &#x2013; N(%)</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">/</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">9 (22.5)</td>
<td valign="top" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">/</td>
<td valign="top" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">10 (25)</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Moderate &#x2013; N(%)</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">8 (20)</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">4 (10)</td>
<td valign="top" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">2 (5)</td>
<td valign="top" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">2 (5)</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Moderate to severe &#x2013; N(%)</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">/</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">2 (5)</td>
<td valign="top" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">/</td>
<td valign="top" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">0 (0)</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Severe &#x2013; N(%)</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">2 (5)</td>
<td valign="middle" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">4 (10)</td>
<td valign="top" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">0 (0)</td>
<td valign="top" align="center" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">0 (0)</td>
</tr>
</tbody></table></table-wrap>
<p><bold>Conclusion</bold>: Utilization of proposed 5 stage grading scheme for evaluation of PRV after TAVI provides more detailed stratification of PVR compared to 3 stage model. The largest difference between models is observed in patients with borderline, mild to moderate PVR. Whether this have implications on patient clinical outcome remains to be determined.</p>
</body>
<back>
<ref-list>
<title>LITERATURE</title>
<ref id="r1"><label>1</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Athappan</surname><given-names>G</given-names></name><name><surname>Patvardhan</surname><given-names>E</given-names></name><name><surname>Tuzcu</surname><given-names>EM</given-names></name><name><surname>Svensson</surname><given-names>LG</given-names></name><name><surname>Lemos</surname><given-names>PA</given-names></name><name><surname>Fraccaro</surname><given-names>C</given-names></name><etal/></person-group> <article-title>Incidence, predictors, and outcomes of aortic regurgitation after transcatheter aortic valve replacement: meta-analysis and systematic review of literature.</article-title> <source>J Am Coll Cardiol</source>. <year>2013</year> Apr 16;<volume>61</volume>(<issue>15</issue>):<fpage>1585</fpage>&#x2013;<lpage>95</lpage>. <pub-id pub-id-type="doi">10.1016/j.jacc.2013.01.047</pub-id><pub-id pub-id-type="pmid">23500308</pub-id></mixed-citation></ref>
<ref id="r2"><label>2</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pibarot</surname><given-names>P</given-names></name><name><surname>Hahn</surname><given-names>RT</given-names></name><name><surname>Weissman</surname><given-names>NJ</given-names></name><name><surname>Monaghan</surname><given-names>MJ</given-names></name></person-group>. <article-title>Assessment of paravalvular regurgitation following TAVR: a proposal of unifying grading scheme.</article-title> <source>JACC Cardiovasc Imaging</source>. <year>2015</year> Mar;<volume>8</volume>(<issue>3</issue>):<fpage>340</fpage>&#x2013;<lpage>60</lpage>. <pub-id pub-id-type="doi">10.1016/j.jcmg.2015.01.008</pub-id><pub-id pub-id-type="pmid">25772838</pub-id></mixed-citation></ref>
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