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<article article-type="abstract" dtd-version="1.0" xml:lang="en" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">CC</journal-id>
<journal-id journal-id-type="nlm-ta">Cardiol Croat</journal-id>
<journal-title-group>
<journal-title>Cardiologia Croatica</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Cardiol. Croat.</abbrev-journal-title>
</journal-title-group>
<issn pub-type="ppub">1848-543X</issn>
<issn pub-type="epub">1848-5448</issn>
<publisher><publisher-name>Croatian Cardiac Society</publisher-name></publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">CC 2022 17_9-10_180</article-id>
<article-id pub-id-type="doi">10.15836/ccar2022.180</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Extended Abstract</subject></subj-group>
<subj-group subj-group-type="subheading"><subject>Arrhythmology and electrostimulation</subject></subj-group>
</article-categories>
<title-group>
<article-title>Transcatheter left atrial appendage occlusion: an early single-center experience</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6587-2315</contrib-id><name><surname>Pa&#x0161;ara</surname><given-names>Vedran</given-names></name><xref ref-type="corresp" rid="cor1">*</xref></contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5870-202X</contrib-id><name><surname>Prepolec</surname><given-names>Ivan</given-names></name></contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0504-5238</contrib-id><name><surname>Pezo-Nikoli&#x0107;</surname><given-names>Borka</given-names></name></contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4721-3236</contrib-id><name><surname>Re&#x0161;kovi&#x0107; Luk&#x0161;i&#x0107;</surname><given-names>Vlatka</given-names></name></contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7349-6137</contrib-id><name><surname>Jak&#x0161;i&#x0107; Jurinjak</surname><given-names>Sandra</given-names></name></contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3603-2242</contrib-id><name><surname>Puljevi&#x0107;</surname><given-names>Davor</given-names></name></contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9101-1570</contrib-id><name><surname>Mili&#x010D;i&#x0107;</surname><given-names>Davor</given-names></name></contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5425-5840</contrib-id><name><surname>Velagi&#x0107;</surname><given-names>Vedran</given-names></name></contrib>
<aff id="aff1"><institution content-type="dept">University of Zagreb School of Medicine</institution>, <institution>University Hospital Centre Zagreb</institution>, <addr-line>Zagreb</addr-line>, <country country="hr">Croatia</country></aff>
</contrib-group>
<author-notes>
<corresp id="cor1"><label>*</label>ADDRESS FOR CORRESPONDENCE: Vedran Pa&#x0161;ara, Klini&#x010D;ki bolni&#x010D;ki centar Zagreb, Ki&#x0161;pati&#x0107;eva 12, HR-10000 Zagreb, Croatia. / Phone: +385-91-7302-512 / E-mail: <email xlink:href="vedran.pasara@gmail.com">vedran.pasara@gmail.com</email></corresp></author-notes>
<pub-date pub-type="epub-ppub"><month>11</month><year>2022</year></pub-date>
<volume>17</volume>
<issue>9-10</issue>
<fpage>180</fpage>
<lpage>180</lpage>
<history>
<date date-type="received"><day>04</day><month>11</month><year>2022</year></date>
<date date-type="accepted"><day>10</day><month>11</month><year>2022</year></date>
</history>
<permissions>
<copyright-year>2022</copyright-year>
<copyright-holder>Croatian Cardiac Society</copyright-holder>
</permissions>
<kwd-group kwd-group-type="author"><title>KEYWORDS: </title><kwd>left atrial appendage</kwd><kwd>atrial fibrillation</kwd><kwd>stroke</kwd></kwd-group>
</article-meta>
</front>
<body>
<p><bold>Introduction</bold>: Transcatheter left atrial appendage occlusion (LAAO) is a stroke prevention method for patients with atrial fibrillation (AF) and increased thromboembolic risk with a contraindication for oral anticoagulation (OAC) or with an elevated bleeding risk under chronic OAC. (<xref ref-type="bibr" rid="r1"><italic>1</italic></xref>) This study aimed to assess patient characteristics, acute success rate, and periprocedural complication rate of transcatheter LAAO procedures in our institution.</p>
<p><bold>Patients and Methods</bold>: This single-center retrospective observational study included all patients who underwent transcatheter LAAO in our center from June 2021 until October 2022. Data were collected from hospital electronic medical records.</p>
<p><bold>Results</bold>: We evaluated all 18 consecutive patients (55.6% male, 72.2 &#x00B1; 6.3 years) who underwent transcatheter LAAO. Patient characteristics and risk factors are shown in <xref ref-type="table" rid="t1"><bold>Table 1</bold></xref>. The acute success rate was 88.9%, two proctored procedures were unsuccessful due to unfavorable anatomy. There were no procedure-related stroke, device embolization, or device-related thrombus. Procedure characteristics are shown in <xref ref-type="table" rid="t2"><bold>Table 2</bold></xref>. Three patients (16.7%) developed postprocedural groin hematoma. One patient developed a femoral arteriovenous fistula and required surgical repair, while another patient developed hemodynamically irrelevant pericardial effusion. During follow-up, there were no thromboembolic complications, and one patient had a bleeding complication with dual antiplatelet therapy.</p>
<table-wrap id="t1" position="float">
<label>TABLE 1</label><caption><title>Patient characteristics and risk factors.</title>
</caption>
<table frame="hsides" rules="groups">
<col width="69.19%"/>
<col width="30.81%"/>
<thead>
<tr>
<th valign="top" align="left" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Male, N (%)</th>
<th valign="top" align="left" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">10 (55.6)</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Age, years</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">72.2 &#x00B1; 6.3</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">BMI, kg/m<sup>2</sup></td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">27.5 &#x00B1; 4.1</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">LVEF, %</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">53.9 &#x00B1; 9.1</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Persistent/permanent AF, N (%)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">9 (50)</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Prior TIA/stroke, N (%)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">4 (22.2)</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Prior major bleeding, N (%)</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">14 (77.8)</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">CHADSVASc</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">3.5 &#x00B1; 1.5</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">HASBLED</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">3.0 &#x00B1; 0,.5</td>
</tr>
</tbody></table></table-wrap>
<table-wrap id="t2" position="float">
<label>TABLE 2</label><caption><title>Procedure characteristics.</title>
</caption>
<table frame="hsides" rules="groups">
<col width="66.43%"/>
<col width="33.57%"/>
<thead>
<tr>
<th valign="top" align="left" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">Procedure time, min</th>
<th valign="top" align="left" scope="col" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">75.8 &#x00B1; 27.6</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Fluoroscopy time, min</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">9.3 &#x00B1; 4.5</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Radiation dose, mGy</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">529.4 &#x00B1; 472.3</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Dose area product, mcGy/m<sup>2</sup></td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">4542.4 &#x00B1; 4132.1</td>
</tr>
<tr>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt" scope="row">Contrast agent, ml</td>
<td valign="top" align="left" style="border-left: solid 0.75pt; border-top: solid 0.25pt; border-right: solid 0.75pt; border-bottom: solid 0.25pt">61.4 &#x00B1; 29.5</td>
</tr>
</tbody></table></table-wrap>
<p><bold>Conclusion</bold>: Our data suggest that, since the introduction of this technology, transcatheter LAAO can be performed in our center with a good rate of acute success and low risk of periprocedural adverse events.</p>
</body>
<back>
<ref-list>
<title>LITERATURE</title>
<ref id="r1"><label>1</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Glikson</surname><given-names>M</given-names></name><name><surname>Wolff</surname><given-names>R</given-names></name><name><surname>Hindricks</surname><given-names>G</given-names></name><name><surname>Mandrola</surname><given-names>J</given-names></name><name><surname>Camm</surname><given-names>AJ</given-names></name><name><surname>Lip</surname><given-names>GYH</given-names></name><etal/><collab>ESC Scientific Document Group</collab></person-group>. <article-title>EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion - an update.</article-title> <source>Europace</source>. <year>2020</year> February 1;<volume>22</volume>(<issue>2</issue>):<fpage>184</fpage>. <pub-id pub-id-type="doi">10.1093/europace/euz258</pub-id><pub-id pub-id-type="pmid">31504441</pub-id></mixed-citation></ref>
</ref-list>
</back>
</article>
